Se-Methylselenocysteine

• CAT Number: I009433
• CAS Number: 26046-90-2
• Molecular Formula: C4H9NO2Se
• Molecular Weight: 182.09
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2R)-2-amino-3-methylselanylpropanoic acid
• InChI: InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
• InChIKey: XDSSPSLGNGIIHP-VKHMYHEASA-N
• SMILES: C[Se]CC(C(=O)O)N

Se-Methylselenocysteine (Cat.No:I009433), also known as MSeC and SeMCys, is a drug potentially for the treatment of solid tumours. Se-methylselenocysteine offers selective protection against organ-specific toxicity induced by clinically active agents and enhances further antitumour activity, resulting in improved therapeutic index. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 expression, which in turn down-regulates Bcl-2 and up-regulates bad expression.

Reference

1:Se-methylselenocysteine suppresses the growth of prostate cancer cell DU145 through connexin 43-induced apoptosis. Lu Z, Qi L, Li GX, Bo XJ, Liu GD, Wang JM.J Cancer Res Ther. 2015 Oct-Dec;11(4):840-5. doi: 10.4103/0973-1482.139265. PMID: 26881528 Free Article2:Analysis of Selenium Levels in Osteosarcoma Patients and the Effects of Se-Methylselenocysteine on Osteosarcoma Cells In Vitro. Huang G, Yong BC, Xu MH, Li JC, Guo HH, Shen JN.Nutr Cancer. 2015;67(5):847-56. doi: 10.1080/01635581.2015.1042548. PMID: 26121331 3:Simultaneous Dual Selective Targeted Delivery of Two Covalent Gemcitabine Immunochemotherapeutics and Complementary Anti-Neoplastic Potency of [Se]-Methylselenocysteine. Coyne CP, Jones T, Bear R.J Cancer Ther. 2015 Jan;6(1):62-89. PMID: 25821636 Free PMC Article4:Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: acute toxicity, genotoxicity and subchronic toxicity. Yang H, Jia X.Regul Toxicol Pharmacol. 2014 Dec;70(3):720-7. doi: 10.1016/j.yrtph.2014.10.014. Epub 2014 Oct 31. PMID: 25444999 5:Se-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines. Wang C, Zeng Z, Liu Q, Zhang R, Ni J.Int J Mol Sci. 2014 Nov 18;15(11):21331-47. doi: 10.3390/ijms151121331. PMID: 25411798 Free PMC Article6:Synthesis of [(77)Se]-methylselenocysteine when preparing sauerkraut in the presence of [(77)Se]-selenite. Metabolic transformation of [ (77)Se]-methylselenocysteine in Wistar rats determined by LC-IDA-ICP-MS. Sánchez-Martínez M, Pérez-Corona T, Martínez-Villaluenga C, Frías J, Peñas E, Porres JM, Urbano G, Cámara C, Madrid Y.Anal Bioanal Chem. 2014 Dec;406(30):7949-58. doi: 10.1007/s00216-014-8224-7. Epub 2014 Oct 14. PMID: 25311192 7:Synergistic effect of Se-methylselenocysteine and vitamin E in ameliorating the acute ethanol-induced oxidative damage in rat. Yao Z, Zhang Y, Li H, Deng Z, Zhang X.J Trace Elem Med Biol. 2015 Jan;29:182-7. doi: 10.1016/j.jtemb.2014.08.004. Epub 2014 Aug 21. PMID: 25213679 8:Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified Brassica sprouts. Avila FW, Yang Y, Faquin V, Ramos SJ, Guilherme LR, Thannhauser TW, Li L.Food Chem. 2014 Dec 15;165:578-86. doi: 10.1016/j.foodchem.2014.05.134. Epub 2014 Jun 4. PMID: 25038715 9:Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Cao S, Durrani FA, Tóth K, Rustum YM.Br J Cancer. 2014 Apr 2;110(7):1733-43. doi: 10.1038/bjc.2014.85. Epub 2014 Mar 11. PMID: 24619073 Free PMC Article10:Evaluation of the respiratory elimination kinetics of selenate and Se-methylselenocysteine after oral administration in lambs. Davis TZ, Stegelmeier BL, Green BT, Welch KD, Hall JO.Res Vet Sci. 2013 Dec;95(3):1163-8. doi: 10.1016/j.rvsc.2013.09.015. Epub 2013 Oct 8. PMID: 24210249