SDZ SER 082 fumarate

• CAT Number: I009351
• CAS Number: 1417343-80-6 (SDZ SER 082 fumarate), 141474-54-6(SDZ SER 082).
• Molecular Formula: C19H24N2O4
• Molecular Weight: 344.411
• Purity: ≥95%
• Synonyms: SDZ SER 082 fumarate; SDZ-SER-082; SDZ SER 082; SDZSER 082.;(+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate
• Target: 5-HT2B/2C receptor antagonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C15H20N2.C4H4O4/c1-16-7-5-12-9-17-8-6-11-3-2-4-13(15(11)17)14(12)10-16;5-3(6)1-2-4(7)8/h2-4,12,14H,5-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t12-,14-;/m1./s1
• InChIKey: DXUZZRDHJMOLTN-MRYVXRNOSA-N
• SMILES: CN1CCC2CN3CCC4=C3C(=CC=C4)C2C1.C(=CC(=O)O)C(=O)O

SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. SDZ SER 082 fumarate iInhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. It also inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).

Reference

1. Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201. PMID: 9570468.2.Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051. PMID: 9408213.