Scopolamine Hydrobromide

  • CAT Number: A000424
  • CAS Number: 114-49-8
  • Molecular Formula: C17H22BrNO4
  • Molecular Weight: 384.3
  • Purity: ≥95%
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Scopolamine Hydrobromide acts as antimuscarinics like atropine, but may have more central nervous system effects. It is a non-selective muscarinic antagonist. Presently, scopolamine hydrobromide is a widely used clinically to treat motion sickness.

Catalog Number A000424
CAS Number 114-49-8
Molecular Formula

C17H22BrNO4

Purity 95%
Target Muscarinic Antagonist
Storage -20°C
Related CAS 114-49-8 (trihydrate)
InChI 1S/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11?,12-,13-,14+,15-,16+;/m1./s1
InChIKey WTGQALLALWYDJH-WYHSTMEOSA-N
SMILES CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br
Reference

1: Chu YY, Hua N, Ru YS, Zhao SZ. [The protection of hydrogen-rich saline on a
rat dry eye model induced by scopolamine hydrobromide]. Zhonghua Yan Ke Za Zhi.
2017 May 11;53(5):363-372. doi: 10.3760/cma.j.issn.0412-4081.2017.05.009.
Chinese. PubMed PMID: 28494565.
<br>

2: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide,
atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in
Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013
Oct;38(19):3291-4. Chinese. PubMed PMID: 24422394.

<br>
3: Xia T, Liu DD, Shi LF, Hu JH. [Pharmacokinetics of scopolamine hydrobromide
oral disintegrative microencapsule tablets in Beagle dogs determined with
LC-MS/MS]. Yao Xue Xue Bao. 2011 Aug;46(8):951-4. Chinese. PubMed PMID: 22007521.

<br>
4: Li FQ, Yan C, Bi J, Lv WL, Ji RR, Chen X, Su JC, Hu JH. A novel spray-dried
nanoparticles-in-microparticles system for formulating scopolamine hydrobromide
into orally disintegrating tablets. Int J Nanomedicine. 2011;6:897-904. doi:
10.2147/IJN.S17900. Epub 2011 Apr 28. PubMed PMID: 21720502; PubMed Central
PMCID: PMC3124395.
<br>

5: Martin-Flores M, Mercure-McKenzie TM, Campoy L, Erb HN, Ludders JW, Gleed RD.
Controlled retrospective study of the effects of eyedrops containing
phenylephrine hydrochloride and scopolamine hydrobromide on mean arterial blood
pressure in anesthetized dogs. Am J Vet Res. 2010 Dec;71(12):1407-12. doi:
10.2460/ajvr.71.12.1407. PubMed PMID: 21117990.
<br>

6: Lü WL, Hu JH, Zhu QG, Li FQ. [Preparation of scopolamine hydrobromide
nanoparticles-in-microsphere system]. Yao Xue Xue Bao. 2010 Jul;45(7):914-9.
Chinese. PubMed PMID: 20931792.
<br>

7: Gupta VD Phd. Chemical stability of scopolamine hydrobromide nasal solution.
Int J Pharm Compd. 2009 Sep-Oct;11(5):438-9. PubMed PMID: 23966527.
<br>

8: Likar R, Rupacher E, Kager H, Molnar M, Pipam W, Sittl R. [Efficacy of
glycopyrronium bromide and scopolamine hydrobromide in patients with death
rattle: a randomized controlled study]. Wien Klin Wochenschr.
2008;120(21-22):679-83. doi: 10.1007/s00508-008-1094-2. German. PubMed PMID:
19116709.
<br>

9: Cao SL, Zhang QZ, Jiang XG. Preparation of ion-activated in situ gel systems
of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy.
Acta Pharmacol Sin. 2007 Apr;28(4):584-90. PubMed PMID: 17376300.

<br>
10: Doty RL, Bagla R, Misra R, Mueller E, Kerr KL. No influence of scopolamine
hydrobromide on odor detection performance of rats. Chem Senses. 2003
Nov;28(9):761-5. PubMed PMID: 14654443.

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