Sclerotiorin

• CAT Number: R067380
• CAS Number: 549-23-5
• Molecular Formula: C₂₁H₂₃ClO₅
• Molecular Weight: 390.86
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1
• InChIKey: SWJLTKXURNHVHE-UPWXJBBJSA-N
• SMILES: CCC(C)C=C(C)C=CC1=CC2=C(C(=O)C(C(=O)C2=CO1)(C)OC(=O)C)Cl

Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-<wbr></wbr>1 with an IC50 value of 4.2 µM. Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),, inhibition of Grb2-<wbr></wbr>Shc interaction (IC50 = 22 µM),, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).

Reference

1.Chidananda, C., and Sattur, A.P. Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. Journal of Agricultural and Food Chemistry 55, 2879-2883 (2007).