SCH-79797

• CAT Number: I009411
• CAS Number: 245520-69-8
• Molecular Formula: C23H27Cl2N5
• Molecular Weight: 444.404
• Purity: ≥95%
• Target: PAR1 antagonist
• Solubility: Soluble in DMSO
• Storage: Desiccate at -20C
• IUPAC Name: 3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine;dihydrochloride
• InChI: InChI=1S/C23H25N5.2ClH/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17;;/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27);2*1H
• InChIKey: NNJTXSQXGHYXAJ-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N.Cl.Cl

SCH-79797 is a potent and selective PAR1 antagonist. SCH-79797 limits myocardial ischemia/reperfusion injury in rat hearts. SCH 79797 protects against ischemia/reperfusion-induced arrhythmias in the rat hearts. SCH 79797 and its N-methyl analog (SCH 203099) inhibited binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP, Ala-Phe(p-F)-Arg-ChA-HArg-[(3)H]Tyr-NH(2)) to PAR-1 with IC(50) values of 70 and 45 nM, respectively.

Reference

1:SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts. Mohamed OY, Al-Masri AA, El Eter EA, Lateef R.Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4796-4800. PMID: 27906419 Free Article2:SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE.Basic Res Cardiol. 2007 Jul;102(4):350-8. Epub 2007 Apr 30. PMID: 17468933 Free PMC Article3:Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Ahn HS, Foster C, Boykow G, Stamford A, Manna M, Graziano M.Biochem Pharmacol. 2000 Nov 15;60(10):1425-34. PMID: 11020444