SCH-1473759 hydrochloride

• CAT Number: I000397
• CAS Number: 1094067-13-6
• Molecular Formula: C20H27ClN8OS
• Molecular Weight: 463
• Purity: ≥95%
• Target: Aurora Kinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 4 nM (Aurora A); 13 nM (Aurora B)[1].
• IUPAC Name: 2-[ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol;hydrochloride
• InChI: InChI=1S/C20H26N8OS.ClH/c1-5-27(20(3,4)12-29)11-15-6-17(30-26-15)25-18-19-21-9-16(14-7-22-23-8-14)28(19)10-13(2)24-18;/h6-10,29H,5,11-12H2,1-4H3,(H,22,23)(H,24,25);1H
• InChIKey: YBAZMWNWFHDNTH-UHFFFAOYSA-N
• SMILES: CCN(CC1=NSC(=C1)NC2=NC(=CN3C2=NC=C3C4=CNN=C4)C)C(C)(C)CO.Cl

SCH-1473759 hydrochloride（Cat No.:I000397） is a potent inhibitor of aurora kinases, specifically targeting aurora kinases A and B. It exhibits a high affinity for these kinases, with IC50 values of 4 nM for aurora kinase A and 13 nM for aurora kinase B. By inhibiting these kinases, SCH-1473759 hydrochloride disrupts the regulation of cell division and proliferation, making it a potential therapeutic agent for diseases characterized by abnormal cell growth, such as cancer.

Reference

[1]. Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.
[2]. Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.