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SC-III3

SC-III3

  • CAT Number: I009416
  • CAS Number: 1660110-65-5
  • Molecular Formula: C19H14ClNO5
  • Molecular Weight: 371.773
  • Purity: ≥95%
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SC-III3 is a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. SC-III3 reduces the viability of HepG2 cells and tumor growth of HepG2 xenograft mouse model. It induces the death of HepG2 cells by a way irrelevant to apoptosis and necrosis.

Catalog Number I009416
CAS Number 1660110-65-5
Molecular Formula

C19H14ClNO5

Purity 95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
Reference

</br>1:SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. Zhao P, Dou Y, Chen L, Li L, Wei Z, Yu J, Wu X, Dai Y, Xia Y.Fitoterapia. 2015 Jul;104:31-40. doi: 10.1016/j.fitote.2015.05.002. Epub 2015 May 8. PMID: 25964188 </br>2:SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. Zhao P, Chen L, Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF, Dai Y.BMC Cancer. 2014 Dec 19;14:987. doi: 10.1186/1471-2407-14-987. PMID: 25527123 Free PMC Article

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