SBP-0636457

• CAT Number: I014800
• CAS Number: 1422180-49-1
• Molecular Formula: C₂₅H₃₆N₄O₄
• Molecular Weight: 456.58
• Purity: ≥95%
• Storage: 4°C, stored under nitrogen
• IUPAC Name: (4S,7S,9aS)-8,8-dimethyl-4-[[(2S)-2-(methylamino)propanoyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-2,3,4,7,9,9a-hexahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide
• InChI: InChI=1S/C25H36N4O4/c1-15(26-4)22(30)28-19-12-13-33-20-14-25(2,3)21(29(20)24(19)32)23(31)27-18-11-7-9-16-8-5-6-10-17(16)18/h5-6,8,10,15,18-21,26H,7,9,11-14H2,1-4H3,(H,27,31)(H,28,30)/t15-,18+,19-,20-,21+/m0/s1
• InChIKey: PBGOFGSVVXGJCA-KDJJVYBXSA-N
• SMILES: CC(C(=O)NC1CCOC2CC(C(N2C1=O)C(=O)NC3CCCC4=CC=CC=C34)(C)C)NC

SBP-0636457 (Cat No.:I014800) is a small molecule compound categorized as a SMAC (Second Mitochondria-Derived Activator of Caspases) mimetic. It functions as an antagonist or inhibitor of apoptosis proteins (IAPs). SBP-0636457 specifically binds to the BIR (baculoviral IAP repeat) domains of IAP proteins, exhibiting a Ki (inhibition constant) value of 0.27 μM. This compound holds potential for research applications focused on solid tumors and hematologic cancers, providing insights into the mechanisms of IAP-mediated apoptosis and exploring novel therapeutic approaches for these malignancies.

Reference

[1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15.[2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.