SB-415286

• CAT Number: I002905
• CAS Number: 264218-23-7
• Molecular Formula: C₁₆H₁₀ClN₃O₅
• Molecular Weight: 359.73
• Purity: ≥95%
• Target: GSK-3
• Solubility: DMSO 50 mg/mL Ethanol 20 mg/mL
• Storage: -20°C
• IC50: 78 nM
• IUPAC Name: 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione
• InChI: InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
• InChIKey: PQCXVIPXISBFPN-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

SB415286 (Cat No.: I002905) is a potent inhibitor of GSK3α with an IC50/Ki of 78 nM/31 nM and also effectively inhibits GSK-3β. This compound can induce growth arrest and apoptosis in multiple myeloma (MM) cells. Its specificity for GSK3α and GSK-3β makes it a valuable tool for research focused on these kinases and their roles in various cellular processes. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

1:A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. Pizarro JG, Folch J, Esparza JL, Jordan J, Pallàs M, Camins A.J Cell Mol Med. 2009 Sep;13(9B):3906-17. doi: 10.1111/j.1582-4934.2008.00389.x. Epub 2008 Jun 20. PMID: 18624766 Free PMC Article2:GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286. Yeste-Velasco M, Folch J, Jiménez A, Rimbau V, Pallàs M, Camins A.Eur J Pharmacol. 2008 Jul 7;588(2-3):239-43. doi: 10.1016/j.ejphar.2008.04.019. Epub 2008 Apr 11. PMID: 18502415 3:Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Pizarro JG, Yeste-Velasco M, Rimbau V, Casadesús G, Smith MA, Pallàs M, Folch J, Camins A.Int J Dev Neurosci. 2008 May-Jun;26(3-4):269-76. doi: 10.1016/j.ijdevneu.2008.02.002. Epub 2008 Feb 8. PMID: 18342477 4:Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. MacAulay K, Hajduch E, Blair AS, Coghlan MP, Smith SA, Hundal HS.Eur J Biochem. 2003 Sep;270(18):3829-38. PMID: 12950267 Free Article