SB-3CT

• CAT Number: I003017
• CAS Number: 292605-14-2
• Molecular Formula: C15H14O3S2
• Molecular Weight: 306.4
• Purity: ≥95%
• Target: MMP2/MMP9 inhibitor
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 13.9 nM/600 nM (MMP2/MMP9) [1]
• InChI: InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
• InChIKey: LSONWRHLFZYHIN-UHFFFAOYSA-N
• SMILES: O=S(C(C=C1)=CC=C1OC2=CC=CC=C2)(CC3SC3)=O

SB-3CT (CAT: I003017) is a selective inhibitor of matrix metalloproteinase (MMP) activity, particularly MMP-2 and MMP-9. It exhibits potential as an anti-metastatic agent by preventing the degradation of extracellular matrix components, such as collagen and gelatin. SB-3CT’s inhibition of MMPs holds promise for applications in cancer therapy and inflammatory disorders, where MMPs play a role in tumor invasion, metastasis, and tissue damage. By targeting specific MMPs, SB-3CT offers a valuable tool for studying their functions and developing therapeutic strategies to combat these pathological processes.

Reference

1:MMP-9 inhibitor SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Jia F, Yin YH, Gao GY, Wang Y, Cen L, Jiang JY.J Neurotrauma. 2014 Jul 1;31(13):1225-34. doi: 10.1089/neu.2013.3230. Epub 2014 Jun 3. PMID: 24661104 Free PMC Article2:QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. Zhou J, Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB.J Chem Theory Comput. 2010 Nov 9;6(11):3580-3587. PMID: 21076643 Free PMC Article3:Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT. Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB.J Phys Chem B. 2010 Jan 21;114(2):1030-7. doi: 10.1021/jp909327y. PMID: 20039633 Free PMC Article4:DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2. Tao P, Fisher JF, Mobashery S, Schlegel HB.Org Lett. 2009 Jun 18;11(12):2559-62. doi: 10.1021/ol9008393. PMID: 19445474 Free PMC Article