SB 297006

• CAT Number: I010915
• CAS Number: 58816-69-6
• Molecular Formula: C18H18N2O5
• Molecular Weight: 342.351
• Purity: ≥95%
• Target: Chemokine Receptors
• Solubility: Soluble to 100 mM in DMSO and to 20 mM in ethanol
• Storage: Store at RT
• IUPAC Name: ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate
• InChI: InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1
• InChIKey: BEZXGSZPWXRHIN-INIZCTEOSA-N
• SMILES: CCOC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2

SB 297006(CAT: I010915) is a potent and selective antagonist of the CCR3 receptor. CCR3 is a chemokine receptor that is primarily expressed in eosinophils, basophils, and Th2 lymphocytes. It plays a role in the recruitment and activation of these cells during allergic and inflammatory responses. SB 297006 specifically blocks the binding of chemokines to the CCR3 receptor, thereby inhibiting its activation and downstream signaling. This makes it a valuable tool for studying the role of CCR3 in various diseases and exploring its potential as a therapeutic target for conditions involving eosinophilic and allergic inflammation.