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SB-218078

SB-218078

  • CAT Number: I009313
  • CAS Number: 135897-06-2
  • Molecular Formula: C24H15N3O3
  • Molecular Weight: 393.402
  • Purity: ≥95%
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SB-218078 (Cat.No:I009313) is a potent and selective indolocarbazole chk1 inhibitor.

Catalog Number I009313
CAS Number 135897-06-2
Molecular Formula

C24H15N3O3

Purity 95%
Target Chk
Solubility Soluble in DMSO, not in water
Storage Store at -20°C
InChI InChI=1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29)
InChIKey OTPNDVKVEAIXTI-UHFFFAOYSA-N
SMILES C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
Reference

</br>1:Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb;41(2):180-188.e4. doi: 10.1016/j.exphem.2012.10.007. Epub 2012 Oct 17. PubMed PMID: 23085462; PubMed Central PMCID: PMC3660094.</br>2:Park JH, Kim WS, Kim JY, Park MH, Nam JH, Yun CW, Kwon YG, Jo I. Chk1 and Hsp90 cooperatively regulate phosphorylation of endothelial nitric oxide synthase at serine 1179. Free Radic Biol Med. 2011 Dec 15;51(12):2217-26. doi: 10.1016/j.freeradbiomed.2011.09.021. Epub 2011 Sep 25. PubMed PMID: 22001744.

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