CONTACT US
Home > Inhibitors/Agonists> > Satraplatin
Satraplatin

Satraplatin

  • CAT Number: I001135
  • CAS Number: 129580-63-8
  • Molecular Formula: C10H22Cl2N2O4Pt
  • Molecular Weight: 500.3
  • Purity: ≥95%
Inquiry Now

Satraplatin (CAT: I001135) is a platinum-based antineoplastic agent that is being investigated for the treatment of advanced prostate cancer in patients who have previously undergone chemotherapy. It belongs to the class of drugs known as platinum analogs, which exert their anticancer effects by forming covalent bonds with DNA, leading to DNA damage and ultimately inhibiting cancer cell growth.

Catalog Number I001135
CAS Number 129580-63-8
Molecular Formula

C10H22Cl2N2O4Pt

Purity 95%
Target DNA Alkylating
Solubility DMSO: ≥ 33 mg/mL
Storage Store at -20°C
Overview of Clinical Research

<span style=”font-family:arial,helvetica,sans-serif;”><span style=”color:#000000;”><span style=”font-size:12px;”>Satraplatin is a&nbsp;<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>DNA cross linking agent and a DNA synthesis inhibitor.&nbsp;</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>No recent reports of development identified for phase-I development in Prostate-cancer(Neoadjuvant therapy) in China (PO, Capsule).</span></span></span></span>

IUPAC Name (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
InChI InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4
InChIKey CKNPWBAXEKSCRG-UHFFFAOYSA-J
SMILES [Cl-][Pt+4]([O-]C(C)=O)([O-]C(C)=O)([Cl-])([NH3])[NH2]C1CCCCC1
Reference

1: Doshi G, Sonpavde G, Sternberg CN. Clinical and pharmacokinetic evaluation of satraplatin. Expert Opin Drug Metab Toxicol. 2012 Jan;8(1):103-11. doi: 10.1517/17425255.2012.636352. Epub 2011 Nov 19. Review. PubMed PMID: 22098065.<br />
2: Bhargava A, Vaishampayan UN. Satraplatin: leading the new generation of oral platinum agents. Expert Opin Investig Drugs. 2009 Nov;18(11):1787-97. doi: 10.1517/13543780903362437. Review. PubMed PMID: 19888874; PubMed Central PMCID: PMC3856359.<br />
3: Sonpavde G, Sternberg CN. Satraplatin for the therapy of castration-resistant prostate cancer. Future Oncol. 2009 Sep;5(7):931-40. doi: 10.2217/fon.09.84. Review. PubMed PMID: 19792961.<br />
4: McKeage MJ. Satraplatin in hormone-refractory prostate cancer and other tumour types: pharmacological properties and clinical evaluation. Drugs. 2007;67(6):859-69. Review. PubMed PMID: 17428104.<br />
5: Kelland LR. An update on satraplatin: the first orally available platinum anticancer drug. Expert Opin Investig Drugs. 2000 Jun;9(6):1373-82. Review. PubMed PMID: 11060749.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!