Sarpogrelate hydrochloride

• CAT Number: I001350
• CAS Number: 135159-51-2
• Molecular Formula: C24H32ClNO6
• Molecular Weight: 465.97
• Purity: ≥95%
• Target: 5-HT Receptor
• Solubility: DMSO: ≥ 62 mg/mL
• Storage: Store at -20C

Sarpogrelate hydrochloride (Cat.No:I001350) is a pharmaceutical compound used as an antiplatelet agent. It acts as a selective serotonin receptor antagonist, particularly targeting the 5-HT2A receptor subtype on platelets. Sarpogrelate hydrochloride is prescribed to inhibit platelet aggregation and is used in the management of conditions like peripheral vascular disease and thromboembolic disorders.

Reference

[1]. Nishio, H., A. Inoue, and Y. Nakata, Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Arch Int Pharmacodyn Ther, 1996. 331(2): p. 189-202.
[2]. Pertz, H. and S. Elz, In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharmacol, 1995. 47(4): p. 310-6.
[3]. Miyazaki, M., et al., Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease. J Cardiovasc Pharmacol, 2007. 49(4): p. 221-7.