For research use only. Not for therapeutic Use.
Saracatinib difumarate(CAT: I036004) is a potent, orally active Src family kinase inhibitor with IC₅₀ values ranging from 2.7 to 11 nM for c-Src, Lck, c-Yes, Lyn, Fyn, Fgr, and Blk. It exhibits high selectivity over non-Src tyrosine kinases, making it an excellent tool for dissecting Src-dependent signaling pathways involved in cancer, inflammation, and bone resorption. Saracatinib has been widely studied in both oncology and neurodegeneration research, including clinical evaluations for solid tumors and Alzheimer’s disease. Its broad activity against Src family members makes it ideal for exploring kinase-targeted therapies and the development of targeted anticancer strategies.
| CAS Number | 893428-72-3 |
| Synonyms | (E)-but-2-enedioic acid;N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine |
| Molecular Formula | C35H40ClN5O13 |
| Purity | ≥95% |
| IUPAC Name | (E)-but-2-enedioic acid;N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine |
| InChI | InChI=1S/C27H32ClN5O5.2C4H4O4/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22;2*5-3(6)1-2-4(7)8/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+ |
| InChIKey | OQXMMAQEMJUIQM-LVEZLNDCSA-N |
| SMILES | CN1CCN(CC1)CCOC2=CC3=C(C(=C2)OC4CCOCC4)C(=NC=N3)NC5=C(C=CC6=C5OCO6)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
