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MK 3118

MK 3118

  • CAT Number: I008058
  • CAS Number: 1207753-03-4
  • Molecular Formula: C44H67N5O4
  • Molecular Weight: 730.051
  • Purity: ≥95%
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MK 3118 is a glucan synthase inhibitor potentially for the treatment of candida infection and aspergillosis.

Catalog Number I008058
CAS Number 1207753-03-4
Molecular Formula

C44H67N5O4

Purity 95%
Target glucan synthase inhibitor
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term, or -20 °C for long term
InChI InChI=1S/C44H67N5O4/c1-27(2)28(3)39(7)18-19-41(9)30-12-13-33-40(8)23-52-25-44(33,31(30)14-17-42(41,10)34(39)37(50)51)22-32(35(40)53-24-43(11,45)38(4,5)6)49-36(47-26-48-49)29-15-20-46-21-16-29/h14-16,20-21,26-28,30,32-35H,12-13,17-19,22-25,45H2,1-11H3,(H,50,51)/t28-,30+,32-,33+,34-,35+,39-,40-,41-,42+,43+,44+/m1/s1
InChIKey BODYFEUFKHPRCK-ZCZMVWJSSA-N
SMILES CC(C)C(C)C1(CCC2(C3CCC4C5(COCC4(C3=CCC2(C1C(=O)O)C)CC(C5OCC(C)(C(C)(C)C)N)N6C(=NC=N6)C7=CC=NC=C7)C)C)C
Reference

</br>1:Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Lamoth F, Alexander BD.Antimicrob Agents Chemother. 2015 Jul;59(7):4308-11. doi: 10.1128/AAC.00234-15. Epub 2015 Apr 20. PMID: 25896696 Free PMC Article</br>2:Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Lepak AJ, Marchillo K, Andes DR.Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72. doi: 10.1128/AAC.04445-14. Epub 2014 Dec 15. PMID: 25512406 Free PMC Article</br>3:Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates. Jiménez-Ortigosa C, Paderu P, Motyl MR, Perlin DS.Antimicrob Agents Chemother. 2014;58(2):1248-51. doi: 10.1128/AAC.02145-13. Epub 2013 Dec 9. PMID: 24323472 Free PMC Article</br>4:In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods. Pfaller MA, Messer SA, Motyl MR, Jones RN, Castanheira M.Antimicrob Agents Chemother. 2013 Feb;57(2):1065-8. doi: 10.1128/AAC.01588-12. Epub 2012 Dec 10. PMID: 23229479 Free PMC Article</br>5:Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST). Pfaller MA, Messer SA, Motyl MR, Jones RN, Castanheira M.J Antimicrob Chemother. 2013 Apr;68(4):858-63. doi: 10.1093/jac/dks466. Epub 2012 Nov 28. PMID: 23190764

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