SAR-020106

• CAT Number: I009280
• CAS Number: 1184843-57-9
• Molecular Formula: C19H19ClN6O
• Molecular Weight: 382.85
• Purity: ≥95%
• Synonyms: SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106.;(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile
• Target: Chk1 inhibitor
• Solubility: soluble in DMSO, not soluble in water.
• Storage: Store at +4C
• IUPAC Name: 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile
• InChI: InChI=1S/C19H19ClN6O/c1-12(11-26(2)3)27-19-16(8-21)22-10-18(25-19)24-17-7-13-5-4-6-15(20)14(13)9-23-17/h4-7,9-10,12H,11H2,1-3H3,(H,23,24,25)/t12-/m1/s1
• InChIKey: SRBJWIBAMIKCMV-GFCCVEGCSA-N
• SMILES: CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl

SAR-020106（Cat No.:I009280） is a potent and selective CHK1 inhibitor that competes with ATP binding. It exhibits an inhibitory concentration (IC50) of 13.3 nM. By targeting CHK1, SAR-020106 hinders the activity of this protein kinase, which plays a crucial role in cell cycle regulation and DNA damage response. The high potency and selectivity of SAR-020106 make it a promising candidate for therapeutic applications, particularly in the treatment of diseases characterized by aberrant cell cycle control.

Reference

1:Targeted radiosensitization by the Chk1 inhibitor SAR-020106. Borst GR, McLaughlin M, Kyula JN, Neijenhuis S, Khan A, Good J, Zaidi S, Powell NG, Meier P, Collins I, Garrett MD, Verheij M, Harrington KJ.Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1110-8. doi: 10.1016/j.ijrobp.2012.08.006. Epub 2012 Sep 14. PMID: 22981708 2:The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Walton MI, Eve PD, Hayes A, Valenti M, De Haven Brandon A, Box G, Boxall KJ, Aherne GW, Eccles SA, Raynaud FI, Williams DH, Reader JC, Collins I, Garrett MD.Mol Cancer Ther. 2010 Jan;9(1):89-100. doi: 10.1158/1535-7163.MCT-09-0938. Epub 2010 Jan 6. PMID: 20053762 Free Article