Sanguinarine

• CAT Number: I002823
• CAS Number: 2447-54-3
• Molecular Formula: C20H14NO4+
• Molecular Weight: 332.33
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene
• InChI: InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
• InChIKey: INVGWHRKADIJHF-UHFFFAOYSA-N
• SMILES: C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6

Sanguinarine (Cat.No:I002823) is a natural alkaloid derived from the bloodroot plant (Sanguinaria canadensis). It has shown diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer effects. Sanguinarine’s ability to induce apoptosis and inhibit cell proliferation makes it a subject of interest in potential therapeutic applications and medicinal research.

Reference

[1]. Cecen E, et al. Promoting effects of sanguinarine on apoptotic gene expression in human neuroblastoma cells. Asian Pac J Cancer Prev. 2014;15(21):9445-51.

[2]. Li W, et al. Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages. Int Immunopharmacol. 2014 Oct;22(2):311-7.

[3]. Ying L, et al. Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation. Acta Pharmacol Sin. 2014 Dec 29.

[4]. Kalogris C, et al. Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition. Biochem Pharmacol. 2014 Aug 1;90(3):226-34.