Salvinorin B Mesylate

• CAT Number: R067109
• CAS Number: 862073-79-8
• Molecular Formula: C22H28O9S
• Molecular Weight: 468.5
• Purity: ≥95%
• Synonyms: Mesyl Sal B
• Storage: -20°C
• InChI: InChI=1S/C22H28O9S/c1-21-7-5-13-20(25)30-16(12-6-8-29-11-12)10-22(13,2)18(21)17(23)15(31-32(4,26)27)9-14(21)19(24)28-3/h6,8,11,13-16,18H,5,7,9-10H2,1-4H3/t13-,14-,15-,16-,18-,21-,22-/m0/s1
• InChIKey: JPQCLBRBPPZECE-VOVNARLJSA-N
• SMILES: [H][C@@]12CC[C@@]([C@@]3([H])[C@@]1(C)C[C@@H](C4=COC=C4)OC2=O)(C)[C@H](C(OC)=O)C[C@H](OS(C)(=O)=O)C3=O

Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A (Item No. 11487) in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively). It is a mesylated version of salvinorin B (Item No. 11488) and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors. In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane. In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.

Reference

1.Harding, W.W.,Tidgewell, K.,Byrd, N., et al. Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands. J. Med. Chem. 48(15), 4765-4771 (2005).