Salubrinal

• CAT Number: I003472
• CAS Number: 405060-95-9
• Molecular Formula: C₂₁H₁₇Cl₃N₄OS
• Molecular Weight: 479.81
• Purity: ≥95%
• Target: eIF2a
• Solubility: DMSO: ≥ 50 mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
• InChIKey: LCOIAYJMPKXARU-VAWYXSNFSA-N
• SMILES: C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

Salubrinal (CAT: I003472) is a selective inhibitor of the cellular endoplasmic reticulum (ER) stress response pathway. It acts by inhibiting the eukaryotic translation initiation factor 2 alpha (eIF2α) dephosphorylation, leading to the attenuation of ER stress-induced translational inhibition. By modulating the ER stress response, salubrinal can regulate protein synthesis, folding, and trafficking within the ER. It has been studied for its potential therapeutic applications in various diseases associated with ER stress, including neurodegenerative disorders, metabolic diseases, and viral infections. Salubrinal offers a valuable tool for investigating the role of the ER stress response pathway in cellular physiology and disease processes.

Reference

1:Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway. Rani S, Sreenivasaiah PK, Cho C, Kim DH.Mol Cells. 2017 Jan;40(1):66-72. doi: 10.14348/molcells.2017.2259. Epub 2017 Jan 26. PMID: 28152298 Free PMC Article2:Neuroprotection by salubrinal treatment in global cerebral ischemia. Anuncibay-Soto B, Santos-Galdiano M, Fernández-López A.Neural Regen Res. 2016 Nov;11(11):1744-1745. doi: 10.4103/1673-5374.194711. No abstract available. PMID: 28123406 Free PMC Article3:Salubrinal protects against Clostridium difficile toxin B-induced CT26 cell death. Chen S, Sun C, Gu H, Wang H, Li S, Ma Y, Wang J.Acta Biochim Biophys Sin (Shanghai). 2017 Mar 1;49(3):228-237. doi: 10.1093/abbs/gmw139. PMID: 28119311 4:Synergistic antitumor activity of the combination of salubrinal and rapamycin against human cholangiocarcinoma cells. Zhao X, Zhang C, Zhou H, Xiao B, Cheng Y, Wang J, Yao F, Duan C, Chen R, Liu Y, Feng C, Li H, Li J, Dai R.Oncotarget. 2016 Dec 20;7(51):85492-85501. doi: 10.18632/oncotarget.13408. PMID: 27863431 Free PMC Article5:Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury. Barreda-Manso MA, Yanguas-Casás N, Nieto-Sampedro M, Romero-Ramírez L.J Cell Physiol. 2017 Jun;232(6):1501-1510. doi: 10.1002/jcp.25655. Epub 2016 Nov 10. PMID: 27753092 6:Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice. Takigawa S, Frondorf B, Liu S, Liu Y, Li B, Sudo A, Wallace JM, Yokota H, Hamamura K.J Pharmacol Sci. 2016 Oct;132(2):154-161. doi: 10.1016/j.jphs.2016.09.006. Epub 2016 Oct 1. PMID: 27743814 Free Article7:VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal. Bastola P, Neums L, Schoenen FJ, Chien J.Mol Oncol. 2016 Dec;10(10):1559-1574. doi: 10.1016/j.molonc.2016.09.005. Epub 2016 Sep 28. PMID: 27729194 Free Article8:Salubrinal attenuates right ventricular hypertrophy and dysfunction in hypoxic pulmonary hypertension of rats. He YY, Liu CL, Li X, Li RJ, Wang LL, He KL.Vascul Pharmacol. 2016 Dec;87:190-198. doi: 10.1016/j.vph.2016.09.009. Epub 2016 Sep 24. PMID: 27678416 9:Salubrinal Suppresses IL-17-Induced Upregulation of MMP-13 and Extracellular Matrix Degradation Through the NF-kB Pathway in Human Nucleus Pulposus Cells. Yao Z, Nie L, Zhao Y, Zhang Y, Liu Y, Li J, Cheng L.Inflammation. 2016 Dec;39(6):1997-2007. PMID: 27590238 10:[Salubrinal protects human lens epithelial cells against endoplasmic reticulum stress-associated apoptosis]. Li Y, Zheng GY, Liu Y.Zhonghua Yan Ke Za Zhi. 2016 Jun 11;52(6):437-43. doi: 10.3760/cma.j.issn.0412-4081.2016.06.008. Chinese. PMID: 27373572