Salidroside

• CAT Number: I000205
• CAS Number: 10338-51-9
• Molecular Formula: C14H20O7
• Molecular Weight: 300.3
• Purity: ≥95%
• Synonyms: Rhodioloside
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• InChIKey: ILRCGYURZSFMEG-RKQHYHRCSA-N

Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.IC50 value:Target:In vitro: Salidroside significantly reduces brain infarct size and cerebral edema. Salidroside could effectively decrease the levels of interleukin-6 (IL-6), interleukin- 1β (IL-1β), and tumor necrosis factor-α (TNF-α) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells [2].In vivo: Plasma, urine, bile, and feces samples were collected frommale rats after a single intragastric gavage of salidroside at a dose of 50 mg/kg. Results indicated that metabolic pathways of salidroside in male rats included hydroxylation, dehydrogenation, lucuronidation, and sulfate conjugation [1]. SD rats were administrated with 50, 100, or 200 mg/kg salidroside for 28 days. BLM-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, and pro-inflammatory cytokine release, and oxidative stress damages in lung tissues were attenuatedby salidroside in a dose-dependent manner [3].

Reference

[1]. Fei Han, et al. Metabolic profile of salidroside in rats using high-performance
liquid chromatography combined with Fourier transform ion
cyclotron resonance mass spectrometry. Anal Bioanal Chem, DOI 10.1007/s00216-015-9080-9

[2]. Tong Chen, et al. Suppressing Receptor-Interacting Protein 140: a New Sight
for Salidroside to Treat Cerebral Ischemia. Mol Neurobiol, DOI 10.1007/s12035-015-9521-7.

[3]. Haiying Tang, et al. Salidroside protects against bleomycin-induced pulmonary
fibrosis: activation of Nrf2-antioxidant signaling, and inhibition
of NF-κB and TGF-β1/Smad-2/-3 pathways. Cell Stress and Chaperones
, DOI 10.1007/s12192-015-0654-4