SAHA- CAS 149647-78-9

CAS No.: 149647-78-9

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SAHA,149647-78-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:A000479
Synonyms:

149647-78-9; SAHA; Suberoylanilide hydroxamic acid; Zolinza; N-hydroxy-N/’-phenyloctanediamide

Molecular Formula:

C₁₄H₂₀N₂O₃

Molecular Weight:264.3
Description:Vorinostat, also known as suberanilohydroxamic acid, MK-0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. Vorinostat/’s inhibition of histone deacetylases results in the accumulation of acetylated histones and acetylated proteins, including transcription factors crucial for the expression of genes needed to induce cell differentiation.
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Vorinostat, also known as suberanilohydroxamic acid, MK-0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. Vorinostat/’s inhibition of histone deacetylases results in the accumulation of acetylated histones and acetylated proteins, including transcription factors crucial for the expression of genes needed to induce cell differentiation. Vorinostat was approved for the treatment of cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after treatment with other medicines.

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