Sacubitril-d4

• CAT Number: C000325
• CAS Number: 1884269-07-1
• Molecular Formula: C₂₄H₂₅D₄NO₅
• Molecular Weight: 415.52
• Purity: ≥95%
• Synonyms: [S-(R*,S*)]-[1,1′-Biphenyl]-4-pentanoic Acid,γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-Ethyl Ester-d4
• Target: Neprilysin
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Appearance: Colourless to Pale Yellow Gel to Solid
• Storage: 4°C

Sacubitril-d4(CAT: C000325) is a deuterium-labeled derivative of Sacubitril. Sacubitril itself is a pharmaceutical compound used in cardiovascular medicine. It acts as a neprilysin inhibitor, which helps increase the levels of beneficial peptides like natriuretic peptides while reducing the degradation of these peptides. In pharmaceutical chemistry, Sacubitril, and its deuterium-labeled counterpart are essential in drug development, particularly for the treatment of heart failure.

Reference

McMurray, J., et al.: N. Eng. J. Med., 371 (2014);