For research use only. Not for therapeutic Use.
Saclofen（Cat No.:R026139）is a selective GABA<sub>B</sub> receptor antagonist commonly used in neuroscience research to study inhibitory neurotransmission. By blocking GABA<sub>B</sub> receptors, saclofen helps delineate the role of G-protein-coupled GABA signaling in synaptic plasticity, nociception, and motor control. Unlike GABA<sub>A</sub> antagonists, it does not affect fast inhibitory transmission. Saclofen is structurally related to baclofen, a GABA<sub>B</sub> agonist, but exerts opposing physiological effects. It is valuable in exploring potential treatments for conditions like spasticity, epilepsy, and addiction. Saclofen is primarily used in experimental settings involving rodent models and electrophysiological assays.
| CAS Number | 125464-42-8 |
| Synonyms | 3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid |
| Molecular Formula | C9H12ClNO3S |
| Purity | ≥95% |
| IUPAC Name | 3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid |
| InChI | InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14) |
| InChIKey | JYLNVJYYQQXNEK-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
