<p style=/line-height:25px/>Lipoic acid inhibits activation of nuclear factor kappa-B, which is involved in AIDS progression.<br>Target: NF-κB [1]<br>Lipoic acid is a powerful antioxidant, in organs of rats submitted to sepsis. Lipoic acid is effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney. Alpha-lipoic acid is a phase 2-inductive nutraceutical, a naturally occurring dithiol compound that functions as an essential cofactor for mitochondrial bioenergetic enzyme. Lipoic acid is recognized as a universal antioxidant capable of scavenging free radicals, chelating metals, regenerating endogenous antioxidants, and modulating various signal transduction pathways. [2] Lipoic acid suppresses HIV replication in cultured cells and enhanced helper T cells in mice. ALA inhibits replication of HIV by reducing the activity of reverse transcriptase, the enzyme responsible for manufacturing the virus from the DNA of lymphocytes.</p>
| Catalog Number | I000737 |
| CAS Number | 1200-22-2 |
| Molecular Formula | C8H14O2S2 |
| Purity | 95% |
| Target | NF-κB [1] |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| Reference | </br>1:Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. Oliveira TQ, Sousa CNS, Vasconcelos GS, de Sousa LC, de Oliveira AA, Patrocínio CFV, Medeiros IDS, Honório Júnior JER, Maes M, Macedo D, Vasconcelos SMM.J Affect Disord. 2017 May 11;219:49-57. doi: 10.1016/j.jad.2017.05.022. [Epub ahead of print] PMID: 28521187 </br>2:[Effect of α-lipoic acid on free radical processes in serum of rats on high fat diet]. Cichoń M, Błaszczyk U, Zalejska-Fiolka J.Med Pr. 2017 May 16;68(3):391-399. doi: 10.13075/mp.5893.00533. Epub 2017 Apr 4. Polish. PMID: 28512366 Free Article</br>3:Effect of Lipoic Acid on the Biochemical Mechanisms of Resistance to Bortezomib in SH-SY5Y Neuroblastoma Cells. Tibullo D, Giallongo C, Puglisi F, Tomassoni D, Camiolo G, Cristaldi M, Brundo MV, Anfuso CD, Lupo G, Stampone T, Li Volti G, Amenta F, Avola R, Bramanti V.Mol Neurobiol. 2017 May 11. doi: 10.1007/s12035-017-0575-6. [Epub ahead of print] PMID: 28497200 </br>4:Soft Ultraviolet (UV) Photopatterning and Metallization of Self-Assembled Monolayers (SAMs) Formed from the Lipoic Acid Ester of α-Hydroxy-1-acetylpyrene: The Generality of Acid-Catalyzed Removal of Thiol-on-Gold SAMs using Soft UV Light. Pukenas L, Prompinit P, Nishitha B, Tate DJ, Singh NDP, Wälti C, Evans SD, Bushby RJ.ACS Appl Mater Interfaces. 2017 May 19. doi: 10.1021/acsami.7b04708. [Epub ahead of print] PMID: 28485941 </br>5:POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION. Al-Ghamdi MA, Choudhry H, Al-Doghather HA, Huwait EH, Kumosani TA, Moselhy SS.Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):272-277. doi: 10.21010/ajtcam.v14i1.29. eCollection 2017. PMID: 28480405 </br>6:Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril. Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA.Cornea. 2017 Jun;36(6):725-731. doi: 10.1097/ICO.0000000000001182. PMID: 28476051 </br>7:Alpha-lipoic acid: An inimitable feed supplement for poultry nutrition. Sohaib M, Anjum FM, Nasir M, Saeed F, Arshad MS, Hussain S.J Anim Physiol Anim Nutr (Berl). 2017 Apr 26. doi: 10.1111/jpn.12693. [Epub ahead of print] Review. PMID: 28447384 </br>8:Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. De Cicco S, Immediata V, Romualdi D, Policola C, Tropea A, Di Florio C, Tagliaferri V, Scarinci E, Della Casa S, Lanzone A, Apa R.Gynecol Endocrinol. 2017 Apr 23:1-4. doi: 10.1080/09513590.2017.1313972. [Epub ahead of print] PMID: 28434274 </br>9:Effect of alpha-lipoic acid on endometrial implants in an experimental rat model. Pınar N, Karapınar OS, Özcan O, Özgür T, Bayraktar S.Fundam Clin Pharmacol. 2017 Apr 21. doi: 10.1111/fcp.12293. [Epub ahead of print] PMID: 28429826 </br>10:Determination of lipoic acid in human urine by capillary zone electrophoresis. Kubalczyk P, Głowacki R.Electrophoresis. 2017 Apr 18. doi: 10.1002/elps.201700002. [Epub ahead of print] PMID: 28418619 |
