S55746 hydrochloride

• CAT Number: I019655
• CAS Number: 1448525-91-4
• Molecular Formula: C₄₃H₄₃ClN₄O₆
• Molecular Weight: 747.28
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(4-hydroxyphenyl)-3-[6-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-1,3-benzodioxol-5-yl]-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
• InChI: InChI=1S/C43H42N4O6/c48-34-15-13-32(14-16-34)47(31-10-2-1-3-11-31)43(50)37-23-39(45-17-7-6-12-38(37)45)35-24-40-41(53-28-52-40)25-36(35)42(49)46-26-30-9-5-4-8-29(30)22-33(46)27-44-18-20-51-21-19-44/h1-5,8-11,13-16,23-25,33,48H,6-7,12,17-22,26-28H2/t33-/m0/s1
• InChIKey: VYXJULKGMXJVGI-XIFFEERXSA-N
• SMILES: C1CCN2C(=C(C=C2C3=CC4=C(C=C3C(=O)N5CC6=CC=CC=C6CC5CN7CCOCC7)OCO4)C(=O)N(C8=CC=CC=C8)C9=CC=C(C=C9)O)C1

S55746 hydrochloride (Cat No.:I019655) is a potent and selective inhibitor targeting the anti-apoptotic protein Bcl-2. By binding to the BH3-binding groove of Bcl-2, it disrupts the interaction between Bcl-2 and pro-apoptotic proteins, leading to the activation of apoptosis in cancer cells. S55746 hydrochloride has demonstrated efficacy in inducing cell death in various cancer cell lines, including those resistant to conventional treatments.

Reference

[1]. Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088.