S130

• CAT Number: I019089
• CAS Number: 1160852-22-1
• Molecular Formula: C₂₄H₂₅N₃O₂
• Molecular Weight: 387.47
• Purity: ≥95%

S130 (Cat.No:I019089) is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 µM. S130 suppresses autophagy flux. S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leads to enhanced cytotoxicity.

Reference

[1]. Fu Y, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 20:1-17.