(S)-(+)-Rolipram

• CAT Number: I005129
• CAS Number: 85416-73-5
• Molecular Formula: C16H21NO3
• Molecular Weight: 275.34
• Purity: ≥95%
• Target: PDE
• Solubility: DMSO 55 mg/mL; Water <1 mg/mL
• Storage: Sealed in dry,Store in freezer, under -20°C
• IUPAC Name: (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
• InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
• InChIKey: HJORMJIFDVBMOB-GFCCVEGCSA-N
• SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

S- (+)-Rolipram（Cat No.:I005129） is a selective inhibitor of human monocyte cyclic AMP-specific phosphodiesterase 4 (PDE4), with an IC50 of 0.75 μM. It primarily acts on the central nervous system and exhibits anti-inflammatory and antidepressant activities. It is important to note that S- (+)-Rolipram is less potent than its R-enantiomer. The compound’s ability to modulate cyclic AMP levels and its effects on various physiological processes contribute to its therapeutic potential in the treatment of inflammation and depression.

Reference

[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.
[2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.