For research use only. Not for therapeutic Use.
(S)-Mirtazapine(CAT: I017449) ((S)-Org3770) is the S(+)-enantiomer of Mirtazapine, displaying distinct pharmacological properties compared to its R(–) counterpart. Unlike the antinociceptive profile of (R)-Mirtazapine, the S-enantiomer demonstrates pronociceptive activity in animal models of acute thermal nociception. Pharmacologically, (S)-Mirtazapine acts as a stereoselective 5-HT2 receptor antagonist, highlighting enantioselective differences in serotonergic modulation. It is primarily metabolized by CYP2D6 and CYP1A2, distinguishing its metabolic pathway from the R-enantiomer, which is mainly CYP3A4-dependent. With its unique activity profile, (S)-Mirtazapine serves as a valuable tool compound for investigating stereoselective serotonin receptor pharmacology, nociception, and antidepressant mechanism studies.
| CAS Number | 61337-87-9 |
| Synonyms | (7S)-5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene |
| Molecular Formula | C17H19N3 |
| Purity | ≥95% |
| IUPAC Name | (7S)-5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene |
| InChI | InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3/t16-/m1/s1 |
| InChIKey | RONZAEMNMFQXRA-MRXNPFEDSA-N |
| SMILES | CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
