(S)-Gossypol acetic acid

• CAT Number: I000679
• CAS Number: 1189561-66-7
• Molecular Formula: C32H34O10
• Molecular Weight: 578.61
• Purity: ≥95%
• Target: Bcl-2
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 18.1μM (Bcl-2), 22.9μM (Bcl-xL)

(S)-Gossypol acetic acid(CAT: I000679), also known as AT-101 or R-(-)-gossypol acetic acid, is a synthetic derivative of gossypol. Gossypol is a natural compound found in cottonseeds and has been studied for its potential anticancer properties. (S)-Gossypol acetic acid functions as a pan-inhibitor of Bcl-2 family proteins, which play a crucial role in regulating apoptosis (cell death) pathways. By inhibiting the anti-apoptotic proteins such as Bcl-2, Bcl-XL, and Mcl-1, (S)-Gossypol acetic acid can promote apoptosis in cancer cells, potentially inhibiting their growth and survival. It has shown promise in preclinical and clinical studies for various types of cancer and is being investigated as a potential therapeutic agent.

Reference

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[2]. Lin, J., et al., Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. Oncol Rep, 2013. 30(2): p. 731-8.

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[4]. El-Sharaky, A.S., et al., Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. Food Chem Toxicol, 2009. 47(11): p. 2735-41.

[5]. Wu, T., et al., [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 1996. 18(5): p. 375-9.