ß-Elemene

• CAT Number: I036650
• CAS Number: 33880-83-0
• Molecular Formula: C15H24
• Molecular Weight: 204.35
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane
• InChI: InChI=1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3/t13-,14+,15-/m1/s1
• InChIKey: OPFTUNCRGUEPRZ-QLFBSQMISA-N
• SMILES: C=C([C@H]1C[C@@H](C(C)=C)[C@](C)(C=C)CC1)C

ß-Elemene (Cat.No:I036650) is an inhibitor of Pak1 activation, and an anti-cancer ingredient isolated from the Chinese traditional herb Curcuma wenyujin.

Reference

1: Zhou K, Wang L, Cheng R, Liu X, Mao S, Yan Y. Elemene Increases Autophagic Apoptosis and Drug Sensitivity in Human Cisplatin (DDP)-Resistant Lung Cancer Cell Line SPC-A-1/DDP By Inducing Beclin-1 Expression. Oncol Res. 2017 May 23. doi: 10.3727/096504017X14954936991990. [Epub ahead of print] PubMed PMID: 28550680.
2: Li J, Yu J, Liu A, Wang Y. Retraction notice to “ß-elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome”: LUNG 86/2 (2014) 144-150. Lung Cancer. 2016 Jun;96:120. doi: 10.1016/j.lungcan.2016.03.003. PubMed PMID: 27133761.
3: Zhu T, Zhao Y, Zhang J, Li L, Zou L, Yao Y, Xu Y. ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6. Int J Oncol. 2011 Feb;38(2):419-26. doi: 10.3892/ijo.2010.855. Epub 2010 Dec 3. PubMed PMID: 21132268.