S-Acetylthioacetic Acid

• CAT Number: R002496
• CAS Number: 1190-93-8
• Molecular Formula: C4H6O3S
• Molecular Weight: 134.149
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 2-acetylsulfanylacetic acid
• InChI: InChI=1S/C4H6O3S/c1-3(5)8-2-4(6)7/h2H2,1H3,(H,6,7)
• InChIKey: QSBWDKUBOZHGOU-UHFFFAOYSA-N
• SMILES: CC(=O)SCC(=O)O

S-Acetylthioacetic Acid (CAS: 1190-93-8) is a compound useful in organic synthesis.

Reference

[1]. Anal Biochem. 1983 Jul 1;132(1):68-73. doi: 10.1016/0003-2697(83)90426-8.
A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay.
Duncan RJ, Weston PD, Wrigglesworth R.
A synthesis of the N-hydroxysuccinimide ester of S-acetylthioacetic acid is described. This material is stable when stored dry and has advantages over the currently available reagents used to introduce sulfhydryl groups into a variety of proteins. Proteins modified with this reagent can be used to prepare conjugates for enzyme immunoassay. The conjugation techniques described cause little or no loss of either enzyme activity or antibody titer and function, and the conjugates contain little polymeric material.
DOI: 10.1016/0003-2697(83)90426-8 PMID: 6353995 [Indexed for MEDLINE]