(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid

• CAT Number: L013718
• CAS Number: 148983-03-3
• Molecular Formula: C25H29NO4
• Molecular Weight: 407.50
• Purity: ≥95%
• IUPAC Name: (2S)-3-cyclohexyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid
• InChI: InChI=1S/C25H29NO4/c1-26(23(24(27)28)15-17-9-3-2-4-10-17)25(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h5-8,11-14,17,22-23H,2-4,9-10,15-16H2,1H3,(H,27,28)/t23-/m0/s1
• InChIKey: SZQWVTJZNYDCRV-QHCPKHFHSA-N
• SMILES: CN([C@@H](CC1CCCCC1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid（Cat No.:L013718）is an Fmoc-protected, non-standard amino acid derivative used in solid-phase peptide synthesis (SPPS). The compound features an (S)-configured α-carbon bearing a cyclohexyl side chain, providing steric bulk and hydrophobicity, along with a methylated amine and an Fmoc group for temporary N-terminal protection. This structure enhances peptide folding and stability, making it useful in synthesizing constrained or membrane-permeable peptides. Its incorporation can modulate bioactivity, resistance to proteolysis, or conformational rigidity, especially in therapeutic peptide development and structural optimization of bioactive peptide candidates.