(S)-10-Hydroxycamptothecin

• CAT Number: I002507
• CAS Number: 19685-09-7
• Molecular Formula: C20H16N2O5
• Molecular Weight: 364.4
• Purity: ≥95%
• Synonyms: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3/’,4/’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Target: Topoisomerase
• Solubility: DMSO:39mg/mL
• Storage: 3 years -20℃ powder
• IUPAC Name: (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
• InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N
• SMILES: O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3)C3=C4)=C4C5)N5C2=O

(S)-10-Hydroxycamptothecin (Cat.No:I002507) is a natural compound derived from Camptotheca acuminata, known for its potent anticancer properties. It inhibits DNA topoisomerase I, causing DNA damage and apoptosis in cancer cells. (S)-10-Hydroxycamptothecin has been extensively studied for its potential as a chemotherapeutic agent, particularly in the treatment of various solid tumors.

Reference

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