RYL-552

• CAT Number: I035845
• CAS Number: 1801444-56-3
• Molecular Formula: C24H17F4NO2
• Molecular Weight: 427.39
• Purity: 98%
• Synonyms: RYL-552
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-Fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one
• InChI: InChI=1S/C24H17F4NO2/c1-14-22(29-20-4-2-3-19(25)21(20)23(14)30)17-9-5-15(6-10-17)13-16-7-11-18(12-8-16)31-24(26,27)28/h2-12H,13H2,1H3,(H,29,30)
• InChIKey: OPUNZJHITPCTFC-UHFFFAOYSA-N
• SMILES: O=C1C(C)=C(C2=CC=C(CC3=CC=C(OC(F)(F)F)C=C3)C=C2)NC4=C1C(F)=CC=C4

RYL-552（Cat No.:I035845） is a newly discovered and potent inhibitor of PfNDH2, which stands for Plasmodium falciparum NADH dehydrogenase 2. PfNDH2 is an enzyme involved in the electron transport chain of the malaria parasite, making it an attractive target for antimalarial drug development. RYL-552 shows strong inhibitory activity against PfNDH2, suggesting its potential as a novel therapeutic agent for the treatment of malaria.

Reference

1: Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L, Rao Y, Yang M. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria. J Med Chem. 2017 Mar 9;60(5):1994-2005. doi: 10.1021/acs.jmedchem.6b01733. Epub 2017 Feb 22. PubMed PMID: 28195463.