RWJ-56110 dihydrochloride

• CAT Number: I008747
• CAS Number: 2387505-58-8
• Molecular Formula: C₄₁H₄₅Cl₄F₂N₇O₃
• Molecular Weight: 863.65
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: (2S)-4-amino-N-benzyl-2-[[(2S)-2-[[1-[(2,6-dichlorophenyl)methyl]-3-(pyrrolidin-1-ylmethyl)indol-6-yl]carbamoylamino]-3-(3,4-difluorophenyl)propanoyl]amino]butanamide;dihydrochloride
• InChI: InChI=1S/C41H43Cl2F2N7O3.2ClH/c42-32-9-6-10-33(43)31(32)25-52-24-28(23-51-17-4-5-18-51)30-13-12-29(21-38(30)52)48-41(55)50-37(20-27-11-14-34(44)35(45)19-27)40(54)49-36(15-16-46)39(53)47-22-26-7-2-1-3-8-26;;/h1-3,6-14,19,21,24,36-37H,4-5,15-18,20,22-23,25,46H2,(H,47,53)(H,49,54)(H2,48,50,55);2*1H/t36-,37-;;/m0../s1
• InChIKey: MGZSVSHDIOPSBO-ZEUUMAKDSA-N
• SMILES: C1CCN(C1)CC2=CN(C3=C2C=CC(=C3)NC(=O)NC(CC4=CC(=C(C=C4)F)F)C(=O)NC(CCN)C(=O)NCC5=CC=CC=C5)CC6=C(C=CC=C6Cl)Cl.Cl.Cl

RWJ-56110 dihydrochloride（Cat No.:I008747) is a chemical compound that acts as a potent and selective inhibitor of the phosphodiesterase 4 (PDE4) enzyme. PDE4 is a key regulator of inflammation and immune responses in the body, and its inhibition can reduce inflammation in various disease states. RWJ-56110 dihydrochloride has shown promising results in preclinical studies as a potential treatment for inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), psoriasis, and inflammatory bowel disease.

Reference

[1]. Andrade-Gordon, et al.Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. oc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.[2]. Panagiota Zania, et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J Pharmacol Exp Ther. 2006 Jul;318(1):246-54.