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Ruxolitinib sulfate

Ruxolitinib sulfate

  • CAT Number: I000388
  • CAS Number: 1092939-16-6
  • Molecular Formula: C17H20N6O4S
  • Molecular Weight: 404.44
  • Purity: ≥95%
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Ruxolitinib sulfate (Cat.No:I000388) is a Janus kinase (JAK) inhibitor approved for the treatment of certain types of myeloproliferative neoplasms, including myelofibrosis and polycythemia vera. By inhibiting JAK1 and JAK2 signaling, Ruxolitinib sulfate helps reduce abnormal cell proliferation and inflammation, offering improved outcomes for patients with these conditions.

Catalog Number I000388
CAS Number 1092939-16-6
Molecular Formula

C17H20N6O4S

Purity 95%
Target JAK
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 3.3 nM/2.8 nM(JAK1/JAK2)
Reference

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<br>[1]. Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117.

<br>[2]. Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366(9), 799-807.

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