RU-301

• CAT Number: I018159
• CAS Number: 1110873-99-8
• Molecular Formula: C21H19F3N4O4S
• Molecular Weight: 480.46
• Purity: ≥95%
• Synonyms: 2-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-N-[2-[2-nitro-4-(trifluoromethyl)anilino]ethyl]benzamide
• InChI: InChI=1S/C21H19F3N4O4S/c1-13-10-15(32-27-13)12-33-19-5-3-2-4-16(19)20(29)26-9-8-25-17-7-6-14(21(22,23)24)11-18(17)28(30)31/h2-7,10-11,25H,8-9,12H2,1H3,(H,26,29)
• InChIKey: BPHPWPNHNGXNPR-UHFFFAOYSA-N
• SMILES: CC1=NOC(=C1)CSC2=CC=CC=C2C(=O)NCCNC3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]

RU-301（Cat No.:I018159）is a small-molecule inhibitor designed to disrupt the interaction between CD47 and signal regulatory protein α (SIRPα), a pathway often exploited by cancer cells to evade immune surveillance. By blocking this “don’t eat me” signal, RU-301 promotes macrophage-mediated phagocytosis of tumor cells, enhancing antitumor immune responses. Preclinical studies highlight its potential in immuno-oncology, particularly in overcoming resistance to standard therapies. RU-301 serves as a valuable tool for exploring innate immune checkpoint blockade, tumor immunology, and the development of novel strategies in cancer immunotherapy research.