RU 24969

• CAT Number: I004505
• CAS Number: 66611-26-5
• Molecular Formula: C14H16N2O
• Molecular Weight: 228.29
• Purity: ≥95%
• Target: 5-HT Receptor
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
• InChIKey: KRVMLPUDAOWOGN-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(NC=C2C3=CCNCC3)C=C1

RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors.IC50 value:Target: 5-HT1A/1B agonistRU 24969 possesses preference for the purported 5-HT1B subtype of central 5-HT1 recognition site. The reported significant linear correlation between hypotensive activity following intravenous (i.v.) administration to anesthetized rats and affinity for the central 5-HT1 binding site could only be maintained by incorporation of the affinity of RU 24969 for its low and 8-OH-DPAT for its high affinity binding site [1]. The drug RU 24969 (10 mg/kg) inhibited the rate of synthesis of 5-HT in rat brain by about 50%. Pretreatment of rats with desmethylimipramine over a longer term or clenbuterol given acutely, treatments known to enhance the behavioural responses of rats to various other 5-HT agonists, did not alter the RU 24969-induced response [2]. RU 24969 (0.03-3.0mg/kg, s.c.) dose-dependently decreased water consumption in water deprived rats [3].

Reference

1:Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Aronsen D, Bukholt N, Schenk S.Psychopharmacology (Berl). 2016 Apr;233(8):1339-47. doi: 10.1007/s00213-016-4225-x. Epub 2016 Feb 9. PMID: 26856853 2:RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Aronsen D, Webster J, Schenk S.Pharmacol Biochem Behav. 2014 Sep;124:1-4. doi: 10.1016/j.pbb.2014.05.008. Epub 2014 May 15. PMID: 24844705 3:Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats. Martinez-Price DL, Geyer MA.Pharmacol Biochem Behav. 2002 Apr;71(4):569-80. PMID: 11888548 4:RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors. Fletcher PJ, Korth KM.Behav Pharmacol. 1999 Mar;10(2):183-93. PMID: 10780831 5:Quinpirole attenuates the striatal immediate early gene expression, but not the hyperactivity, induced by the serotonin agonist RU-24969. Cook DF, Wirtshafter D.Brain Res. 2000 Jan 10;852(2):247-54. PMID: 10678749 6:RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Parsons LH, Koob GF, Weiss F.Synapse. 1999 May;32(2):132-5. No abstract available. PMID: 10231132 7:GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat. Chaouloff F, Courvoisier H, Moisan MP, Mormède P.Psychopharmacology (Berl). 1999 Jan;141(3):326-31. PMID: 10027515 8:RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Harrison AA, Parsons LH, Koob GF, Markou A.Psychopharmacology (Berl). 1999 Jan;141(3):242-50. PMID: 10027505 9:GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. O/’Neill MF, Fernández AG, Palacios JM.Pharmacol Biochem Behav. 1996 Mar;53(3):535-9. PMID: 8866952 10:RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors. Kalkman HO.Naunyn Schmiedebergs Arch Pharmacol. 1995 Nov;352(5):583-4. PMID: 8751090