InChI | InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22?,24+,29+,30-,31-,33-/m1/s1 |
Reference | </br>1:The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. Liu X, Ward K, Xavier C, Jann J, Clark AF, Pang IH, Wu H.Redox Biol. 2016 Aug;8:98-109. doi: 10.1016/j.redox.2015.12.005. Epub 2015 Dec 19. PMID: 26773873 Free PMC Article</br>2:Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers. Reisman SA, Goldsberry AR, Lee CY, O/’Grady ML, Proksch JW, Ward KW, Meyer CJ.BMC Dermatol. 2015 Jul 14;15:10. doi: 10.1186/s12895-015-0029-7. PMID: 26170027 Free PMC Article</br>3:RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. Probst BL, Trevino I, McCauley L, Bumeister R, Dulubova I, Wigley WC, Ferguson DA.PLoS One. 2015 Apr 21;10(4):e0122942. doi: 10.1371/journal.pone.0122942. eCollection 2015. PMID: 25897966 Free PMC Article</br>4:The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Goldman DC, Alexeev V, Lash E, Guha C, Rodeck U, Fleming WH.Radiat Res. 2015 Mar;183(3):338-44. doi: 10.1667/RR13900.1. Epub 2015 Mar 4. PMID: 25738896 </br>5:Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Reisman SA, Lee CY, Meyer CJ, Proksch JW, Sonis ST, Ward KW.Radiat Res. 2014 May;181(5):512-20. doi: 10.1667/RR13578.1. Epub 2014 Apr 10. PMID: 24720753 </br>6:Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin. Reisman SA, Lee CY, Meyer CJ, Proksch JW, Ward KW.Arch Dermatol Res. 2014 Jul;306(5):447-54. doi: 10.1007/s00403-013-1433-7. Epub 2013 Dec 22. PMID: 24362512
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