RSV-604

• CAT Number: I004544
• CAS Number: 676128-63-5
• Molecular Formula: C₂₂H₁₇FN₄O₂
• Molecular Weight: 388.4
• Purity: ≥95%
• Target: RSV inhibitor
• Solubility: DMSO:33mg/mL
• Storage: Store at -20°C
• IC50: 0.86 uM(EC50) [1]
• InChI: InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m1/s1
• InChIKey: MTPVBMVUENFFLL-HXUWFJFHSA-N
• SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F

RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) [1]Target: RSV inhibitorRSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease.

Reference

1:Mechanism of action for respiratory syncytial virus inhibitor RSV604. Challa S, Scott AD, Yuzhakov O, Zhou Y, Tiong-Yip CL, Gao N, Thresher J, Yu Q.Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. doi: 10.1128/AAC.04119-14. Epub 2014 Dec 1. PMID: 25451060 Free PMC Article2:RSV604, a novel inhibitor of respiratory syncytial virus replication. Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL.Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. Epub 2007 Jun 18. PMID: 17576833 Free PMC Article