RSL3 1S,3R

• CAT Number: I000842
• CAS Number: 1219810-16-8
• Molecular Formula: C23H21ClN2O5
• Molecular Weight: 440.88
• Purity: ≥95%
• Synonyms: (1S,3R)-methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
• Target: Lipid Metabolism
• Solubility: Soluble in DMSO to 31 mg/mL
• Storage: Store at -20C
• IC50: 100 nM
• InChI: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1
• InChIKey: TXJZRSRTYPUYRW-NQIIRXRSSA-N
• SMILES: O=C(OC)[C@@H]1N(C(CCl)=O)[C@@H](C2=CC=C(C(OC)=O)C=C2)C3=C(C(C=CC=C4)=C4N3)C1

RSL3 1S,3R(CAT: I000842) is a chemical compound that has garnered interest in the field of pharmaceutical and chemical research. This compound is a derivative of RSL3, which is known for its potential anticancer properties. RSL3 and its analogs are inhibitors of the glutathione peroxidase 4 (GPX4) enzyme, which plays a crucial role in protecting cells from oxidative damage.

Reference

[1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death. Front Oncol. 2015, 5: 131.
[2]. Michel We?wer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826.
[3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.