Diltiazem hydrochloride

• CAT Number: I013922
• CAS Number: 33286-22-5
• Molecular Formula: C₂₂H₂₇ClN₂O₄S
• Molecular Weight: 450.98
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride
• InChI: InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• InChIKey: HDRXZJPWHTXQRI-BHDTVMLSSA-N
• SMILES: CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

Diltiazem hydrochloride (Cat No.:I013922) is a medication classified as a calcium channel blocker. It is prescribed for the treatment of conditions such as high blood pressure, angina, and certain heart rhythm disorders. Diltiazem hydrochloride helps reduce blood pressure and improve blood flow to the heart by relaxing and widening the blood vessels. It is available in different forms, including tablets and injections, and is typically taken orally. Diltiazem hydrochloride is widely used to manage various cardiovascular conditions and is known for its effectiveness in regulating heart function.

Reference

[1]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.[2]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.[3]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.[4]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [5]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author//’s transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.