(RS)-AMPA

• CAT Number: I004812
• CAS Number: 74341-63-2
• Molecular Formula: C7H10N2O4
• Molecular Weight: 186.167
• Purity: ≥95%
• Target: AMPAR
• Solubility: Soluble to 10 mM in water with gentle warming
• Storage: Store at RT
• IUPAC Name: 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
• InChI: InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
• InChIKey: UUDAMDVQRQNNHZ-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)NO1)CC(C(=O)O)N

AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, CAT: I004812) is the prototypical and defining agonist for the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subgroup of ionotropic glutamate receptors. Glutamate receptors are critical for excitatory neurotransmission in the central nervous system. Activation of AMPA receptors by AMPA leads to the influx of cations, particularly sodium (Na+) and calcium (Ca2+), into the postsynaptic neuron, resulting in neuronal depolarization and the initiation of excitatory synaptic transmission. AMPA receptors play a fundamental role in synaptic plasticity, learning, and memory processes.

Reference

1: Rainbow TC, Wieczorek CM, Halpain S. Quantitative autoradiography of binding
sites for [3H]AMPA, a structural analogue of glutamic acid. Brain Res. 1984 Aug
20;309(1):173-7. PubMed PMID: 6091846.

2: Honoré T, Lauridsen J, Krogsgaard-Larsen P. The binding of [3H]AMPA, a
structural analogue of glutamic acid, to rat brain membranes. J Neurochem. 1982
Jan;38(1):173-8. PubMed PMID: 6125564.