(R,R)-CXCR2-IN-2

• CAT Number: I045534
• CAS Number: 1838123-22-0
• Molecular Formula: C18H23ClN2O5S
• Molecular Weight: 414.90
• Purity: ≥95%
• Synonyms: 1-[4-chloro-2-hydroxy-3-[(3R)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]urea
• InChI: InChI=1S/C18H23ClN2O5S/c1-11-4-3-5-13(11)20-17(23)21-14-7-6-12(19)16(15(14)22)27(24,25)18(2)8-9-26-10-18/h4,6-7,13,22H,3,5,8-10H2,1-2H3,(H2,20,21,23)/t13-,18-/m1/s1
• InChIKey: DNXKACKCTLURQN-FZKQIMNGSA-N
• SMILES: CC1=CCCC1NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)C3(CCOC3)C)O

(R,R)-CXCR2-IN-2 (Cat No.: I045534) is a potent and selective small-molecule inhibitor of C-X-C chemokine receptor type 2 (CXCR2), a G protein–coupled receptor involved in neutrophil recruitment, inflammation, and cancer progression. By blocking CXCR2-mediated signaling, this compound suppresses chemokine-driven cellular migration and inflammatory responses. It is widely used in preclinical research to explore the therapeutic potential of CXCR2 inhibition in conditions such as autoimmune diseases, chronic inflammation, and tumor microenvironment modulation, offering insights into targeted anti-inflammatory and anticancer strategies.

Reference

[1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
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