Rottlerin

• CAT Number: I009189
• CAS Number: 82-08-6
• Molecular Formula: C30H28O8
• Molecular Weight: 516.54
• Purity: ≥95%
• Target: PKC
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
• InChI: InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
• InChIKey: DEZFNHCVIZBHBI-ZHACJKMWSA-N
• SMILES: CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)C=CC4=CC=CC=C4)OC(C=C3)(C)C)O)O

Rottlerin (Cat No.:I009189) is a natural compound isolated from the Mallotus philippensis tree and is a protein kinase C (PKC) inhibitor. It also has several other pharmacological effects, including inhibition of mitochondrial permeability transition pore (mPTP) opening and antioxidant activity.

Reference

1:Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. Ietta F, Maioli E, Daveri E, Gonzaga Oliveira J, da Silva RJ, Romagnoli R, Cresti L, Maria Avanzati A, Paulesu L, Barbosa BF, Gomes AO, Roberto Mineo J, Ferro EAV.Sci Rep. 2017 Apr 28;7(1):1279. doi: 10.1038/s41598-017-01525-6. PMID: 28455500 Free PMC Article2:Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. Zhu Y, Wang M, Zhao X, Zhang L, Wu Y, Wang B, Hu W.Oncotarget. 2017 Apr 4;8(14):22825-22834. doi: 10.18632/oncotarget.15221. PMID: 28423559 Free PMC Article3:Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. Misuth M, Horvath D, Miskovsky P, Huntosova V.Photodiagnosis Photodyn Ther. 2017 Mar 31. pii: S1572-1000(16)30266-6. doi: 10.1016/j.pdpdt.2017.03.018. [Epub ahead of print] PMID: 28373118 4:Rottlerin-induced autophagy leads to apoptosis in bladder cancer cells. Qi P, He Z, Zhang L, Fan Y, Wang Z.Oncol Lett. 2016 Dec;12(6):4577-4583. doi: 10.3892/ol.2016.5255. Epub 2016 Oct 13. PMID: 28101215 Free PMC Article5:Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. Zhao Z, Zheng N, Wang L, Hou Y, Zhou X, Wang Z.Oncotarget. 2017 Jan 31;8(5):7827-7838. doi: 10.18632/oncotarget.13974. PMID: 27999199 Free PMC Article6:The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strünker T, Strutz-Seebohm N, Greber B, Scherkenbeck J, Seebohm G.Cell Physiol Biochem. 2016;40(6):1549-1558. doi: 10.1159/000453205. Epub 2016 Dec 21. PMID: 27997884 Free Article7:Stimulation of Suicidal Erythrocyte Death by Rottlerin. Mischitelli M, Jemaà M, Almasry M, Faggio C, Lang F.Cell Physiol Biochem. 2016;40(3-4):558-566. Epub 2016 Nov 25. PMID: 27889758 Free Article8:Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells. Su J, Wang L, Yin X, Zhao Z, Hou Y, Ye X, Zhou X, Wang Z.Am J Cancer Res. 2016 Oct 1;6(10):2178-2191. eCollection 2016. PMID: 27822410 Free PMC Article9:Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. Wang L, Hou Y, Yin X, Su J, Zhao Z, Ye X, Zhou X, Zhou L, Wang Z.Oncotarget. 2016 Oct 25;7(43):69770-69782. doi: 10.18632/oncotarget.11974. PMID: 27626499 Free PMC Article10:Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. Yin X, Zhang Y, Su J, Hou Y, Wang L, Ye X, Zhao Z, Zhou X, Li Y, Wang Z.Oncotarget. 2016 Oct 11;7(41):66512-66524. doi: 10.18632/oncotarget.11614. PMID: 27582552 Free PMC Article