For research use only. Not for therapeutic Use.
Rodatristat（Cat No.:I029986）is an orally bioavailable small-molecule inhibitor of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis. By blocking peripheral serotonin production, it reduces serotonin-driven vascular remodeling and inflammation, making it a promising therapeutic candidate for pulmonary arterial hypertension (PAH) and other serotonin-related disorders. Unlike centrally acting inhibitors, Rodatristat is designed to minimize penetration across the blood–brain barrier, preserving normal brain serotonin function. This selectivity provides a safer profile for long-term use. Rodatristat is a valuable research tool in cardiovascular and pulmonary disease studies.
| CAS Number | 1673568-73-4 |
| Synonyms | (3S)-8-[2-amino-6-[(1R)-1-(4-chloro-2-phenylphenyl)-2,2,2-trifluoroethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid |
| Molecular Formula | C27H27ClF3N5O3 |
| Purity | ≥95% |
| IUPAC Name | (3S)-8-[2-amino-6-[(1R)-1-(4-chloro-2-phenylphenyl)-2,2,2-trifluoroethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid |
| InChI | InChI=1S/C27H27ClF3N5O3/c28-17-6-7-18(19(12-17)16-4-2-1-3-5-16)23(27(29,30)31)39-22-13-21(34-25(32)35-22)36-10-8-26(9-11-36)14-20(24(37)38)33-15-26/h1-7,12-13,20,23,33H,8-11,14-15H2,(H,37,38)(H2,32,34,35)/t20-,23+/m0/s1 |
| InChIKey | ZNSPHKJFQDEABI-NZQKXSOJSA-N |
| SMILES | C1CN(CCC12C[C@H](NC2)C(=O)O)C3=CC(=NC(=N3)N)O[C@H](C4=C(C=C(C=C4)Cl)C5=CC=CC=C5)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
