Rocuronium Bromide

• CAT Number: A000651
• CAS Number: 119302-91-9
• Molecular Formula: C32H53N2O4.Br
• Molecular Weight: 609.68
• Purity: ≥95%
• Synonyms: ORG 9426
• Target: AChR
• Solubility: >30.5mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;bromide
• InChI: InChI=1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-;/m0./s1
• InChIKey: OYTJKRAYGYRUJK-FMCCZJBLSA-M
• SMILES: CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]

Rocuronium Bromide(CAT: A000651) is a competitive AchR antagonist, used in modern anesthesia. Rocuronium bromide (RB), an aminosteroid-type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. This product is used for medical research and development and other scientific research purposes.

Overview of Clinical Research

Rocuronium Bromide is a cholinergic receptor modulator and a neuromuscular blocking agent. 

Reference

1.Zan, Umit, Mehmet Topaktas, and Erman Salih Istifli. "In vitro genotoxicity of rocuronium bromide in human peripheral lymphocytes." Cytotechnology 63.3 (2011): 239-245.
2.Anzenbacherova, Eva, et al. "Interaction of rocuronium with human liver cytochromes P450." Journal of Pharmacological Sciences 127.2 (2015): 190-195.
3.Auer, Ulrike, and Yves Moens. "Neuromuscular blockade with rocuronium bromide for ophthalmic surgery in horses." Veterinary ophthalmology 14.4 (2011): 244-247.
4.Tachibana, Masaki, et al. "Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats." Pharmacology 68.2 (2003): 96-104.