Ro 46-2005

• CAT Number: I001867
• CAS Number: 150725-87-4
• Molecular Formula: C23H27N3O6S
• Molecular Weight: 473.54
• Purity: ≥95%
• Target: Endothelin
• Solubility: DMSO: ≥ 28 mg/mL
• Storage: Desiccate at RT
• IC50: 220 nM (ETA) [2]

Ro 46-2005 (Cat.No:I001867) is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

Reference

1:Characterisation of the endothelin receptor mediating contraction of human pulmonary artery using BQ123 and Ro 46-2005. Buchan KW, Magnusson H, Rabe KF, Sumner MJ, Watts IS.Eur J Pharmacol. 1994 Aug 1;260(2-3):221-6. PMID: 7988646 2:Comparison of PD 145065 and Ro 46-2005 as antagonists of contractions of guinea-pig airways induced by endothelin-1 or IRL 1620. Battistini B, Warner TD, Fournier A, Vane JR.Eur J Pharmacol. 1994 Feb 11;252(3):341-5. PMID: 8162956 3:In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. Breu V, Löffler BM, Clozel M.FEBS Lett. 1993 Nov 15;334(2):210-4. PMID: 8224248 Free Article4:Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma. Löffler BM, Breu V, Clozel M.FEBS Lett. 1993 Oct 25;333(1-2):108-10. PMID: 8224145 Free Article5:In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology. Clozel M, Breu V, Gray GA, Löffler BM.J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9. PMID: 7509992