RO 20-1724

• CAT Number: I009102
• CAS Number: 29925-17-5
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.352
• Purity: ≥95%
• Target: PDE
• Solubility: Soluble in DMSO
• Storage: Store at RT
• IUPAC Name: 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
• InChI: InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
• InChIKey: PDMUULPVBYQBBK-UHFFFAOYSA-N
• SMILES: CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC

Ro20-1724 (Cat.No:I009102) is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)

Reference

1:Chronic exposure to Ro20-1724 protects dopaminergic neurons in vitro against the neurotoxic action of N-methyl-D-aspartate and 1-methyl-4-phenylpyridinium. Dickie BG, Greenfield SA.Brain Res. 1997 Apr 11;753(2):335-9. PMID: 9125421 2:Effects of cyclic nucleotide phosphodiesterase IV inhibitor, Ro20,1724, on pancreatic exocrine secretion in dog. Iwatsuki K, Ren LM, Chiba S.Clin Exp Pharmacol Physiol. 1994 Sep;21(9):701-7. PMID: 7529665 3:The synthesis and degradation of poly(a)-containing mRNAs in mouse neuroblastoma cells treated with dibutyryl cAMP or with Ro20-1724. Morrison MR, Hall CL, Pardue S, Brodeur R, Baskin F, Rosenberg RN.J Neurochem. 1980 Jan;34(1):50-8. No abstract available. PMID: 6108985